Metabolism of chondrocytes in osteoarthritis: why all this activity?

1. Sharif M, Kirwan J, Charni N, Sandell LJ, Whittles C, Garnero P. A 5-year longitundinal study of type IIA collagen synthesis and total type II collagen degradation in patients with knee osteoarthritis — Association with disease progression. Rheumatology (Oxford) 2007;46:938-43. 2. Fukui N, Ikeda Y, Ohnuki T, Tanaka Hikita A, Mitomi H, Mori T, Juji T, Katsuragawa Y, Yamamoto S, Sawabe M, Yamane SS, Suzuki R, Sandell LJ, Ochi T. Regional differences in chondrocyte metabolism in osteoarthritis. Arthritis Rheum 2008;58:154-63. 3. Sandell LJ. Modern molecular analysis of a traditional disease: progression in osteoarthritis. Arthritis Rheum 2007;56:2474-7. 4. Sandell LJ. Anabolic factors in degenerative joint disease. Curr Drug Targets 2007;8:359-65. 5. Fukui N, Sandell LJ. Anabolic aspects of cartilage repair. In: Bronner F, Farach-Carson MC, editors. Topics in Bone Biology, Volume 4. Bone and Osteoarthritis. Springer-Verlag; 2007. p. 97-108. 6. Sandell LJ, Xiaoyun X, Franz C, Davies S, Chang L, Patra D. Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1ß. Osteoarthritis Cartilage 2008; (in press). J Musculoskelet Neuronal Interact 2008; 8(4):307